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pentobarbital will lower the extent or result of bosentan by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Unidentified.pentobarbital will reduce the level or result of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 in